GENERAL CATALOGUE
Antitumor agent-169
HY-162643 · 50 mg
MedChemExpress · Cat: HY-162643
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Manufacturer product page
medchemexpress.com/antitumor-agent-169.htmlCatalog No: HY-162643
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
Antitumor agent-169 Compound B3 is a dual inhibitor PD-1/PD-L1 interaction and PARP7, with IC50s of 0.426 ?M and 2.50 nM. Antitumor agent-169 exhibits an affinity to human PD-L1, with Ki of 20.2 nM. Antitumor agent-169 restores the T cell function, increases IFN-? secretion. Antitumor agent-169 inhibits cell viability of MDA-MB-231 and Jurkat T, exhibits antitumor efficacy against melanoma in mouse model and good pharmacokinetic characteristics.
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