Antitumor agent-174

Description

Antitumor agent-174 Compound 10 directly engages the N-terminal site of Hsp90 and promotes the degradation of ?-catenin, thereby suppressing the Wnt/?-catenin signaling. Antitumor agent-174 effectively inhibits proliferation, induce S and G2/M phases arrest and block the clonogenic ability in CRC cells. Antitumor agent-174 down-regulates CDK1, Cyclin D1, c-Myc, Cyclin B1, and Cyclin A2, and upregulaties P21 proteins. Antitumor agent-174 has significant anti-tumor efficacy against colorectal cancer CRC with excellent pharmacokinetics and low toxicity.