Antitumor agent-200

Description

Antitumor agent-200 Compound 2g is a microtubule synthesis inhibitor. By binding to the colchicine site of tubulin, it causes G2/M cell cycle arrest and generates reactive oxygen species ROS . Antitumor agent-200 exhibits significant inhibitory activity against MCF7/ADR and KBV200 cell lines with overexpression of P-glycoprotein P-gp , with drug resistance indices DRI of 0.83 and 0.58 respectively. In the MCF-7 xenograft model, Antitumor agent-200 25 mg/kg, intraperitoneal injection can achieve a tumor growth inhibition rate of 57.2 %. Antitumor agent-200 can be used in the research of the anti-cancer field.