Antiviral agent 35

Description

Antiviral agent 35 compound 4d is an orally active and potent influenza virus inhibitor, acting function in the early stage of virus replication. Antiviral agent 35 inhibits ROS accumulation, autophagy and apoptosis induced by influenza virus, and also inhibits inflammatory response mediated by RIG-1 pathway in mouse model with pulmonary infection. Antiviral agent 35 shows little cytotoxicity with CC50 >800 ?M in MDCK cells, and anti-H1N1 A/Weiss/43 activity with EC50 of 2.28 ?M.