GENERAL CATALOGUE
AO-176
HY-P991561 · 1 mg
MedChemExpress · Cat: HY-P991561
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Manufacturer product page
medchemexpress.com/ao-176.htmlCatalog No: HY-P991561
CAS No: 2691109-74-5
Category: Immunology Inflammation
Pack Size: 1 mg
Brand: MedChemExpress
Description
AO-176 is a humanized anti-CD47 IgG2 monoclonal antibody. AO-176 induces tumor phagocytosis through blocking the CD47-SIRP? interaction. AO-176 preferentially binds to tumor versus normal cells and directly kills tumor by a cell autonomous mechanism not ADCC antibody-dependent cell-mediated cytotoxicity . AO-176 demonstrates dose-dependent antitumor activity in tumor xenograft models. AO-176 can be used for the researches of cancer, such as lymphoma.
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