APAF1 Mouse Monoclonal Antibody

Description

EnkiLife offers the APAF1 Mouse Monoclonal Antibody. This antibody reacts with Human species and is suitable for ICC,ELISA,FC application. Alternative Names of Immunogen: CED4; APAF-1. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: ICC 1:100-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400 Background: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.