GENERAL CATALOGUE
Apcin
HY-110287 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-110287
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Catalog No: HY-110287
CAS No: 300815-04-7
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome APC/C Cdc20 E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis.
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