GENERAL CATALOGUE
APH02174
HY-174455 · 50 mg
MedChemExpress · Cat: HY-174455
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Catalog No: HY-174455
CAS No: 3065494-66-5
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
APH02174 is a highly selective and orally active IRAK4 PROTAC degrader with the DC50 of 4.01 nM in THP-1 cells. APH02174 blocks inflammatory signals by inhibiting IL-6 release. APH02174 can be used for research on inflammatory conditions such as psoriasis vulgaris and rheumatoid arthritis. Pink: IRAK4 Ligand HY-174470 ; Blue: CRBN Ligand HY-45512 ; Black: Linker; CRBN Ligand+Linker HY-174796
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