GENERAL CATALOGUE
API-1
HY-110077 · 5 mg
MedChemExpress · Cat: HY-110077
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Catalog No: HY-110077
CAS No: 36707-00-3
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
API-1 is a potent selective Akt/PKB inhibitor that reduces the level of phosphorylated Akt IC50 = 0.8 ?M . API-1 binds to the PH domain and inhibits Akt membrane translocation. API-1 induces c-FLIP degradation. API-1 reduces cell proliferation and induces apoptosis. API-1 decreases tumor growth in mouse xenograft model.
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