ARE‐luc‐CMVH Stably Expressing RAW264.7 Cell Line

Description

The RAW-ARE-luc-CMVH Stable RAW264.7 Cell Line is specifically designed for the study of the antioxidant response element ARE pathway, a crucial mechanism in cellular defense against oxidative stress. This cell line, based on the RAW264.7 murine macrophage lineage, stably incorporates a luciferase reporter gene under the control of an ARE-responsive promoter, enhanced by a cytomegalovirus CMV enhancer. This setup enables precise, real-time tracking of ARE activation in response to oxidative stressors and toxicological compounds. It is particularly useful in pharmacological research, allowing for the screening and evaluation of drugs that modulate oxidative stress responses, potentially offering therapeutic strategies for diseases characterized by oxidative damage, such as neurodegenerative disorders and cancer. The cell line ensures consistent performance with its stable reporter gene integration, facilitating reliable and reproducible results in studies of oxidative stress and cellular defense mechanisms. Complete list of cell lines from this panel: Cat. T6529 - NFATlucCMVH Stably Expressing RAW264.7 Cell Line Cat. T6530 - AP1lucCMVH Stably Expressing RAW264.7 Cell Line Cat. T6531 - ARElucCMVH Stably Expressing RAW264.7 Cell Line