GENERAL CATALOGUE
ARN25657
HY-176287 · 50 mg
MedChemExpress · Cat: HY-176287
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medchemexpress.com/arn25657.html
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Catalog No: HY-176287
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
ARN25657 is a dual-acting D3R/GSK-3? modulator. ARN25657 has both partial D3R agonist activity EC50 = 15.2 nM, Ki =1.5 nM and potent GSK-3? inhibitor activity IC50 = 19.3 nM . ARN25657 exhibits excellent GSK-3? selectivity over FYN, PKA, and CDK5/p35. ARN25657 inhibits P-glycoprotein P-gP -mediated acetoxymethyl calcein efflux and improves in vitro ADME properties while maintaining a balanced dual-target profile. ARN25657 is useful for studying bipolar disorder and related neuropsychiatric disorders.
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