GENERAL CATALOGUE
ARS-1323-alkyne
HY-128522 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-128522
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medchemexpress.com/ars-1323-alkyne.htmlCatalog No: HY-128522
CAS No: 2436544-27-1
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
ARS-1323-alkyne is a covalent inhibitor probe that covalently binds to the Switch-II pocket S-IIP of the KRAS G12C mutant protein. ARS-1323-alkyne visualizes the covalent modification of KRAS G12C and quantitatively measures the binding efficiency of the inhibitor to the target. ARS-1323-alkyne can be used to validate the target occupancy of KRAS G12C inhibitors and the synergistic mechanism of combination therapy, providing tool support for the development of combination treatment strategies.