GENERAL CATALOGUE
Articaine
HY-B0516A · 50 mg
MedChemExpress · Cat: HY-B0516A
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Catalog No: HY-B0516A
CAS No: 23964-58-1
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
Articaine Hoe-045 is a selective inhibitor of voltage-gated sodium channels such as rNav1.4, hNav1.7, and rNav1.8 , with an IC50 of 15.8 ?M for open-state Na+ channels, and IC50 of 40.6 ?M and 378 ?M for inactivated and resting-state Na+ channels, respectively. Articaine exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-?B activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine can be used in the study of dental local anesthesia and inflammatory-related diseases such as acute kidney injury .
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