Articaine hydrochloride

Description

Articaine Hoe-045 hydrochloride is a selective inhibitor of voltage-gated sodium channels such as rNav1.4, hNav1.7, and rNav1.8 , with an IC50 of 15.8 ?M for open-state Na+ channels, and IC50 of 40.6 ?M and 378 ?M for inactivated and resting-state Na+ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-?B activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases such as acute kidney injury .