GENERAL CATALOGUE
AS-99 TFA
HY-141429A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-141429A
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medchemexpress.com/as-99-tfa.html
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Catalog No: HY-141429A
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor IC50= 0.79 ?M, Kd= 0.89 ?M with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo.
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