GENERAL CATALOGUE
AS2553627
HY-123187 · 50 mg
MedChemExpress · Cat: HY-123187
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Manufacturer product page
medchemexpress.com/as2553627.htmlCatalog No: HY-123187
CAS No: 1251906-10-1
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
AS2553627 is a type of JAK inhibitor, with IC50 values of 0.46, 0.30, 0.14, and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively. AS2553627 can inhibit the proliferation of human and rat T cells stimulated by IL-2, with IC50 values of 2.4 and 4.3 nM, respectively. AS2553627 can reduce cardiac allograft vasculopathy and fibrosis in a rat heart transplant model, effectively extending survival rates. AS2553627 can be used to prevent acute and chronic rejection in heart transplants.
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