GENERAL CATALOGUE
AS2863619 free base
HY-126675 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-126675
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medchemexpress.com/as2863619-free-base.htmlCatalog No: HY-126675
CAS No: 2241300-50-3
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T Treg cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 CDK8 and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene.
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