GENERAL CATALOGUE
AS2863619
HY-126675A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-126675A
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medchemexpress.com/as2863619.htmlCatalog No: HY-126675A
CAS No: 2241300-51-4
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
AS2863619 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T Treg cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 CDK8 and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene.