GENERAL CATALOGUE
ASX-173
HY-175282 · 5 mg
MedChemExpress · Cat: HY-175282
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Catalog No: HY-175282
CAS No: 2748800-08-8
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
ASX-173 is an orally active inhibitor of asparagine synthetase ASNS IC50 = 0.113 ?M, Ki = 0.4 nM . ASX-173 enhances the anticancer activity of L-asparaginase ASNase HY-P1923 . ASX-173 disrupts nucleotide synthesis and induces leukemia cell cycle arrest, apoptosis and autophagy in leukemia cells in combination with ASNase. ASX-173 slows the growth of OCI-AML2 xenografts in combination with ASNase. ASX-173 is indicated for the study of acute lymphoblastic leukemia, acute myeloid leukemia, colorectal cancer, and other cancers.
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