GENERAL CATALOGUE
Atezolizumab-MMAE
HY-171572 · 500 g
MedChemExpress · Cat: HY-171572
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medchemexpress.com/atezolizumab-mmae.htmlCatalog No: HY-171572
Category: Antibody-drug Conjugate ADC Related
Pack Size: 500 g
Brand: MedChemExpress
Description
Atezolizumab-MMAE is an anti-PD-L1 antibody-drug conjugate ADC with an EC50 of 1.1 nM. Atezolizumab-MMAE is composed of a humanized anti-PD-L1 antibody Atezolizumab HY-P9904 , a lysosomally cleavable dipeptide linker valine-citrulline , a tubulin inhibitor MMAE HY-15162 , and the drug-linker conjugate for ADC is VcMMAE HY-15575 . Atezolizumab-MMAE has a potent cytotoxicity EC50: 9.75-11.94 nM and immune activation effect. Atezolizumab-MMAE has a significantly anti-tumor activity in MC38 xenograft PD-1-humanized immune system mice model.
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