ATM (9F7) Mouse Monoclonal Antibody

Description

EnkiLife offers the ATM (9F7) Mouse Monoclonal Antibody. This antibody reacts with Human,Rat,Mouse species and is suitable for IHC application. Alternative Names of Immunogen: ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:50-1:100 Background: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Research Area: Epigenetics and Nuclear Signaling