GENERAL CATALOGUE
ATM-IN-2
HY-174989 · 50 mg
MedChemExpress · Cat: HY-174989
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Catalog No: HY-174989
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
ATM-IN-2 is a selective and orally active ATM inhibitor with an IC50 of 4 nM. ATM-IN-2 exhibits excellent kinase selectivity 700-fold over PIKK family members. ATM-IN-2 exerts its anti-tumor effect by inhibiting ATM phosphorylation and the downstream signaling pathways p53, H2AX , and promotes cell apoptosis. ATM-IN-2 can be used for the study of chemosensitizer candidate such as colon cancer.
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