Atopaxar hydrochloride

Description

Atopaxar hydrochloride E5555 hydrochloride is the hydrochloride salt form of Atopaxar HY-18200 . Atopaxar hydrochloride is an orally active, selective and reversible antagonist for thrombin receptor protease-activated receptor-1 PAR-1 . Atopaxar hydrochloride is the inhibitor for Janus kinase 1 JAK1 and JAK2, which inhibits the JAK-STAT with EC50 of 5.90 ?M in A549. Atopaxar hydrochloride inhibits the cell viability of A549 IC50=7.02 ?M , arrests the cell cycle at G1 phase and induces apoptosis. Atopaxar hydrochloride exhibits antiplatelet and antitumor activities. Atopaxar hydrochloride can be used for the research of atherothrombotic disease.