GENERAL CATALOGUE
ATR/PARP1-IN-1
HY-174828 · 50 mg
MedChemExpress · Cat: HY-174828
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Manufacturer product page
medchemexpress.com/atr-parp1-in-1.htmlCatalog No: HY-174828
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
ATR/PARP1-IN-1 is a potent ATR and PARP1 dual inhibitor with IC50s of 17.3 nM and 0.38 nM, respectively. ATR/PARP1-IN-1 effectively reduces cell viability, induces apoptosis and DNA damage. ATR/PARP1-IN-1 significantly impairs triple-negative breast cancer TNBC colony formation, migration, and invasion. ATR/PARP1-IN-1 suppresses tumor growth effectively in MDA-MB-468 xenografted mice, with no significant body weight change.
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