GENERAL CATALOGUE
AurkA allosteric-IN-1
HY-158038 · 50 mg
MedChemExpress · Cat: HY-158038
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medchemexpress.com/aurka-allosteric-in-1.htmlCatalog No: HY-158038
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
AurkA allosteric-IN-1 compound 6h is an Aurora A AurkA inhibitor IC50: 6.50 ?M that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA.
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