GENERAL CATALOGUE
Aurora kinase inhibitor-14
HY-158618 · 50 mg
MedChemExpress · Cat: HY-158618
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medchemexpress.com/aurora-kinase-inhibitor-14.htmlCatalog No: HY-158618
CAS No: 958226-81-8
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
Aurora kinase inhibitor-14 Compound 79 is an orally active and highly selective inhibitor of Aurora kinases with IC50 values of 0.5 nM and 1.2 nM for Aurora A and Aurora B, respectively. Aurora kinase inhibitor-14 binds to the ATP-binding site of Aurora kinases to block chromosome segregation during mitosis and induce apoptosis in tumor cells. Aurora kinase inhibitor-14 is promising for research of various solid tumors and hematological malignancies, such as non-small cell lung cancer, breast cancer, and acute myeloid leukemia.