AVN-101

Description

AVN-101 is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist Ki of 153 pM , with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors Ki values of 2.04 nM, 1.56 ?nM, and 1.17? nM, respectively . AVN-101 also exhibits a rather high affinity toward histamine H1 Ki of 0.58 nM and adrenergic ?2A, ?2B, and ?2C Ki= 0.41-3.6 nM receptors. AVN-101 can be studied in such diseases as general anxiety disorders, depression, schizophrenia, AlzheimerAAasAasAas disease, and multiple sclerosis.