GENERAL CATALOGUE
Axl-IN-18
HY-162103 · 50 mg
MedChemExpress · Cat: HY-162103
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Manufacturer product page
medchemexpress.com/axl-in-18.htmlCatalog No: HY-162103
CAS No: 3040329-68-5
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
Axl-IN-18 compound 25c is a potent and selective type II AXL inhibitor. Axl-IN-18 shows excellent AXL inhibitory activity IC50=1.1 nM and 343-fold selectivity over the highly homologous kinase MET in biochemical assays IC50=377 nM . Axl-IN-18 significantly inhibits AXL-driven cell proliferation, dose-dependently suppresses 4T1 cell migration and invasion, and induces apoptosis. Axl-IN-18 shows noticeable antitumor efficacy in a BaF3/TEL-AXL xenograft model.
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