AY-4

Description

AY-4 Compound AY-4 is an efficient PROTAC degrader targeting FTH1 Kd = 3.17 nM . AY-4 effectively upregulates the levels of ferrous Fe2+ and ferric Fe3+ ions in cells. AY-4 is a potential anticancer candidate compound that regulates iron homeostasis through ferritin degradation and enhances the efficacy of existing drugs. AY-4 can effectively reduce the level of FTH1 in breast cancer cells Pink: FTH1 ligand AY-2 HY-174871 ; Blue: E3 ligand Pomalidomide HY-10984 ; Black: Linker, Pomalidomide-PEG3-acid HY-174872 .