GENERAL CATALOGUE
AZ0108
HY-100847 · 5 mg
MedChemExpress · Cat: HY-100847
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Catalog No: HY-100847
CAS No: 1825345-52-5
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
AZ0108 is an inhibitor for poly ADP-ribose polymerase PARP , which inhibits PARP1, PARP2, PARP3, PARP6, TNKS1, TNKS2, with IC50s of 0.03, <0.03, 2.8, 0.083, 3.2, 3 ?M, respectively. AZ0108 prevents centrosome clustering with an EC50 of 0.053 ?M, and exhibits cytotoxicity in cell OCI-LY-19 with GI50 of 0.017 ?M. AZ0108 exhibits good in vivo pharmacokinetic characters in rat/mouse models.
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