GENERAL CATALOGUE
AZD2716
HY-120078 · 1 mg
MedChemExpress · Cat: HY-120078
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medchemexpress.com/azd2716.htmlCatalog No: HY-120078
CAS No: 1845753-81-2
Category: Metabolic Enzyme Protease
Pack Size: 1 mg
Brand: MedChemExpress
Description
AZD2716 is a selective sPLA2 secretory phospholipase A2 inhibitor. AZD2716 significantly reduces the production of pro-inflammatory lipids by inhibiting sPLA2-IIa IC50 = 10 nM , sPLA2-V IC50 = 40 nM , and sPLA2-X IC50 = 400 nM , thereby decreasing macrophage activation and foam cell formation. AZD2716 is promising for studying mechanisms related to atherosclerosis and inflammatory diseases associated with sPLA2.
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