GENERAL CATALOGUE
AZD4625
HY-146223 · 1 mg
MedChemExpress · Cat: HY-146223
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Catalog No: HY-146223
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
AZD4625 is an orally active, selective irreversible, covalent allosteric GTPase KRASG12C inhibitor with an IC50 of 3 nM. AZD4625 can inhibit the MAPK pathway with decreased pCRAF, pMEK, and pERK and the PI3K pathway with decreased pAKT and pS6 , and induce cell apoptosis. AZD4625 has no binding and inhibition of wild-type RAS or isoforms carrying non-KRASG12C mutations. AZD4625 can be used for the study of KRASG12C mutant non-small cell lung cancer.
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