Azvudine

Description

Azvudine RO-0622 is a potent nucleoside reverse transcriptase inhibitor NRTI , with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 EC50s ranging from 0.03 to 6.92 nM and HIV-2 EC50s ranging from 0.018 to 0.025 nM . Azvudine inhibits NRTI-resistant viral strains. Azvudine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction CuAAc with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition SPAAC reactions with molecules containing DBCO or BCN groups.