B/B Homodimerizer

Description

The B/B Homodimerizer is a membrane-permeant ligand that causes homodimerization of proteins fused to dimerization domain B DmrB -provided in the iDimerize Inducible Homodimer System Cat. No. 635068 . NOTE: The B/B Homodimerizer is identical to the AP20187 ligand previously supplied in the ARGENT Regulated Homodimerization Kit from ARIAD Pharmaceuticals, Inc. Our products are to be used forResearch Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval. Back Signal transduction example 2.Inducible mouse model for prostate cancer. iDimerize Inducible Homodimer technology was used to characterize the role of different FGF receptor subtypes FGFR1andFGFR2 in prostate cancer. Transgenic mice which express conditionally active alleles ofFGFR1orFGFR2in prostate tissue were treated with B/B Homodimerizer and monitored for prostate cancer.FGFR1, but notFGFR2, was found to play a role in prostate cancer development Freeman, K. W.,et al. 2003 Cancer Res.63 23 :82568563 . Back Back Exploiting fas-mediated apoptosis to induce programmed cell death.Fas-mediated apoptosis is triggered by trimerization of the fas receptor FasR via its interaction with the fas ligand FasL on an adjacent cell left . This FasR trimerization event activates the caspase 8 pathway. In the MaFIA mouse model, the fas death domain is fused to two repeats of a dimerization domain and expressed from a myeloid-specific promoter. Apoptosis of macrophage cells in this mouse is induced by treatment with B/B Homodimerizer AP20187 right . Back