B/B Homodimerizer

Description

The B/B Homodimerizer is a membrane-permeant ligand that causes homodimerization of proteins fused to dimerization domain B DmrB provided in the iDimerize Inducible Homodimer System Cat. No. 635068 . NOTE: The B/B Homodimerizer is identical to the AP20187 ligand previously supplied in the ARGENT Regulated Homodimerization Kit from ARIAD Pharmaceuticals, Inc. Our products are to be used forResearch Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval. Back Signal transduction example 2.Inducible mouse model for prostate cancer. iDimerize Inducible Homodimer technology was used to characterize the role of different FGF receptor subtypes FGFR1andFGFR2 in prostate cancer. Transgenic mice which express conditionally active alleles ofFGFR1orFGFR2in prostate tissue were treated with B/B Homodimerizer and monitored for prostate cancer.FGFR1, but notFGFR2, was found to play a role in prostate cancer development Freeman, K. W.,et al. 2003 Cancer Res.63 23 :82568563 . Back Back Back