BAG1 Antibody, mAb, Rabbit

Description

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor NEF promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain NBD of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain SBD of HSPA8/HSC70.