BAG3/HSP70-IN-1

Description

BAG3/HSP70-IN-1 compound 16 is the first-in-class BAG3 and HSP70 dual inhibitor. BAG3/HSP70-IN-1 binds to BAG3 full-length, BAG3-BD, and HSP70 proteins with Kds of 33.10 ?M, 27.90 ?M, and 33.80 ?M, respectively. BAG3/HSP70-IN-1 inhibits HeLa cells with an IC50 of 49.46 ?M. BAG3/HSP70-IN-1 induces apoptosis by activating caspase 3 and caspase 9 levels in HeLa cells. BAG3/HSP70-IN-1 elevates p21 levels while reduces FOXM1 expression in HeLa cells. BAG3/HSP70-IN-1 decreases ATPase activity.