GENERAL CATALOGUE
Basroparib
HY-147245 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-147245
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Catalog No: HY-147245
CAS No: 1858179-75-5
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Basroparib STP1002 is a selective, orally active inhibitor of tankyrase TNKS1/TNKS2 with IC50 of 29.94 nM and 3.68 nM for TNKS1 and TNKS2, respectively. Basroparib has an IC50 of >10 ?M for PARP1. Basroparib binds to TNKS, stabilizes AXIN1/2 proteins, blocks Wnt/?-catenin signaling pathway, inhibits tumor cell proliferation and induces apoptosis, while reducing cancer stem cell properties. Basroparib can be used in colorectal cancer CRC studies with KRAS mutations such as G12V/G12D to overcome acquired resistance to MEK inhibitors. STP1002 has synergistic antitumor activity with MEK inhibitors.
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