GENERAL CATALOGUE
BAY 2476568
HY-134877 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-134877
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medchemexpress.com/bay-2476568.htmlCatalog No: HY-134877
CAS No: 2311901-93-4
Category: JAK STAT Signaling
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
BAY 2476568 is a potent and mutant-selective inhibitor targeting EGFR exon20 insertion variants. BAY 2476568 potently inhibits the kinase activity of EGFR exon20 insertion mutants insASV, insSVD, insNPG with IC50 values of 0.09 nM, 0.21 nM, and 0.11 nM, respectively. BAY 2476568 inhibits EGFR Y1068 phosphorylation and reduces the phosphorylation of ERK1/2 and Akt S473 in Ba/F3 cells expressing EGFR exon20 insertion mutants insASV, insSVD . BAY 2476568 can be used for the study of non-small cell lung cancer NSCLC driven by EGFR exon20 insertion mutations.
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