GENERAL CATALOGUE
BAY 61-3606 dihydrochloride
HY-14985 · 5 mg
MedChemExpress · Cat: HY-14985
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Manufacturer product page
medchemexpress.com/BAY-61-3606-dihydrochloride.htmlCatalog No: HY-14985
CAS No: 648903-57-5
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
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