GENERAL CATALOGUE
BAY 61-3606
HY-76474 · 50 mg
MedChemExpress · Cat: HY-76474
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medchemexpress.com/bay-61-3606.htmlCatalog No: HY-76474
CAS No: 732983-37-8
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
BAY 61-3606 is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM. BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 induces a large decrease of Syk phosphorylation in K-rn cell lysates. Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
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