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BAY 61-3606 hydrochloride
GENERAL CATALOGUE

BAY 61-3606 hydrochloride

HY-76474A · 5 mg

MedChemExpress · Cat: HY-76474A

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Catalog No: HY-76474A
CAS No: 1615197-10-8
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress

Description

BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.

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