BD-1008-d5 dihydrobromide

Description

BD-1008-d5 dihydrobromide is the deuterium labeled BD-1008 dihydrobromide HY-100966 . BD-1008 dihydrobromide is a nonselective ? receptor antagonist with Kis against ?1 receptor and ?2 receptor of 2 nM and 8 nM. The BD-1008 dihydrobromide has an extremely low affinity for the D2 receptor Ki = 1112 nM and dopamine transporter DAT Ki 10,000 nM. BD-1008 dihydrobromide significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the ?? receptor. BD-1008 dihydrobromide blocks the self-administration behavior of ? agonists.BD-1008 dihydrobromide can be used for the study of addiction therapy that target the ? receptor.