beta-Amyloid (1-42), human

Description

This peptide is well suited to the quantitative determination of A 42 peptide. Alzheimers disease AD is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles NFTs in the brain. The major protein component of these plaques is beta amyloid peptide A , a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase BACE and a putative gamma secretase. Increased release of the longer forms of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors.