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Bexotegrast
GENERAL CATALOGUE

Bexotegrast

HY-137561 · Free Sample (0.1 - 0.2 mg)

MedChemExpress · Cat: HY-137561

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medchemexpress.com/bexotegrast.html
Catalog No: HY-137561
CAS No: 2376257-44-0
Category: Cytoskeleton
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress

Description

Bexotegrast PLN-74809 is an orally active, potent dual ?v?6/?v?1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits ?v?6- and ?v?1-induced TGF-? activation with IC50 values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-? activation in the fibrotic lung.

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