BFMO

Description

BFMO is a bidentate ligand for copper Cu catalysts that can effectively promote copper-catalyzed N-arylation coupling reactions of hetero aryl bromides with aniline, cyclic secondary amines, and acyclic secondary amines. BFMO coordinates with copper ions to form stable catalytically active species, which reduces the activation energy of the reaction and improves the reactivity of the substrate. It exhibits excellent selectivity for coupling of acyclic secondary amines with large steric hindrance, and can achieve direct monoarylation of piperazine with hetero aryl bromides to generate important pharmaceutical structural units.