GENERAL CATALOGUE
BI-4020
HY-129550 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-129550
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Manufacturer product page
medchemexpress.com/bi-4020.htmlCatalog No: HY-129550
CAS No: 2664214-60-0
Category: JAK STAT Signaling
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. BI-4020 inhibits not only the triple mutant EGFR del19 T790M C797S variant IC50=0.2 nM in BaF3 cell lines but also the double mutant EGFR del19 T790M and primary mutant EGFR del19 IC50=1 nM . BI-4020 also shows activity against EGFR wt IC50=190 nM . BI-4020 shows high kinome selectivity and good DMPK properties.
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