GENERAL CATALOGUE
BI-4732
HY-161275 · 1 mg
MedChemExpress · Cat: HY-161275
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medchemexpress.com/bi-4732.htmlCatalog No: HY-161275
CAS No: 2769715-68-4
Category: JAK STAT Signaling
Pack Size: 1 mg
Brand: MedChemExpress
Description
BI-4732 is an orally active, reversible, ATP-competitive EGFR inhibitor with blood-brain barrier penetration. BI-4732 inhibits the kinase activity of EGFR L858R, T790M and C797S with IC50 values of 1 nM while sparing EGFR wild-type. BI-4732 inhibits EGFR and reduces the phosphorylation of AKT, ERK, and S6K. BI-4732 demonstrates excellent intracranial anti-tumor efficacy in YU-1097 xenograft model harboring EGFRE19del/T790M/C797S. BI-4732 can be used for the study of non-small cell lung cancer NSCLC .
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