BI-9627

Description

BI-9627, a chemical probe, is a potent sodium-hydrogen exchanger isoform 1 NHE1 inhibitor IC50 = 6 and 31 nM in intracellular pH recovery pHi and human platelet swelling assays . BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 decreases autophagy in HTR-8/SVneo cells. BI-9627 can significantly reduce the pHi of human sperm and partially reverse the effect of DMA. BI-9627 prolongs Ca2+ recovery time in KO hiPSC-CMs. BI-9627 shows low DDI agent-agent interaction potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.