BI8622

Description

BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 ?M. BI8622 can decrease the protein expression levels of c-myc and glycolytic markers as well as immune modulatory markers after HUWE1 inhibition in triple-negative breast cancer TNBC cell lines. BI8622 significantly protects against cisplatin HY-17394 -induced acute kidney injury AKI . BI8622 significantly reduces the growth of multiple myeloma MM cell lines and induces cell cycle arrest. BI8622 can prevent HUWE1-dependent TTBK2 ubiquitination. BI8622 can be studied in research for various diseases including medulloblastoma, acute kidney injury, breast cancer and MM.